Polynucleotides
Healthier, firmer skin that still looks like you. Polynucleotides are a regenerative injectable that stimulates your skin's own repair, building collagen and elastin, improving hydration and strengthening the skin from within.

About The Treatment
What are polynucleotides?
Polynucleotides are injectable biostimulators that repair and regenerate the skin at a cellular level. Rather than replacing volume like a dermal filler, or mainly hydrating like a skin booster, they prompt the skin to repair itself. They stimulate cells called fibroblasts to produce fresh collagen and elastin, improve hydration, and strengthen the skin’s support structure, building healthier, stronger skin over the following weeks and months.
How do polynucleotides work?
Polynucleotides work on the fibroblast cells that produce collagen and elastin. They also improve the skin’s blood supply, calm inflammation and support the skin’s natural repair. Instead of covering the signs of ageing, they improve the skin’s health and quality, so the change is gradual and looks natural.
What can polynucleotides treat, and are they right for me?
Polynucleotides suit people who want to improve skin quality without surgery, and they are particularly effective around the delicate under-eye area. They are commonly used to improve:
- Under-eye dark circles and tired-looking eyes
- Fine lines and crepey skin
- Dull, uneven texture and sun damage
- Loss of firmness on the face, neck and décolletage
- Ageing, thinning skin on the hands
- Redness linked to rosacea
They suit both younger patients wanting to slow the early signs of ageing and more mature patients wanting to restore skin quality. At your consultation, Dr Cat will confirm whether polynucleotides are the right choice, or suggest a better option if not.
How polynucleotides compare
Polynucleotides vs Profhilo
Both improve skin quality but work differently. Profhilo is a hyaluronic acid treatment that mainly hydrates the skin and stimulates a little collagen, so it suits dehydrated or dull skin and mild laxity. Polynucleotides trigger the skin’s own repair, building collagen and elastin, calming inflammation, and strengthening the skin, making them a strong choice for crepey skin, dark circles, sun damage, and rosacea-prone skin. You can combine the two, and Dr Cat will advise what suits you.
Polynucleotides vs tear trough filler
Both can improve tired-looking eyes, but they solve different problems. Tear trough filler replaces lost volume under the eye. Polynucleotides improve the quality of the under-eye skin itself, building collagen and strengthening delicate tissue. For thin, crepey skin or dark circles caused by skin quality rather than lost volume, polynucleotides often give a natural improvement without adding filler. Some people do best with a combination.
Benefits of polynucleotides
What to Expect
Your Polynucleotides Journey at Teeth & Face
01
Consultation
Meet Dr Cat for a full skin assessment and to confirm whether polynucleotides suit your goals.
02
Your treatment plan
A plan built around your skin quality, facial anatomy and the result you want.
03
Treatment
A topical numbing cream can be applied, then polynucleotides are placed with a series of tiny injections. Usually 30 to 45 minutes.
04
Recovery
Mild redness, swelling or small bumps are possible for 24 to 48 hours and settle quickly.
05
Your results
Skin quality improves as collagen builds, with most people noticing a difference after the second session.
Dr Cat is wonderful, first rate service with a true understanding of aesthetics and what will work for me as an individual. She has got me looking and feeling great, will absolutely be back!
VERIFIED TEETH & FACE PATIENT
★★★★★

Patient Experiences
What Our Facial Aesthetics Patients Say
Hundreds of Birmingham patients have trusted us with their skin and confidence. Here's what they said.
Why choose us
Why Choose Teeth & Face for Polynucleotides

Resident plastic surgeon-led
Every injectable treatment is carried out by Dr Cat, Resident Plastic Surgeon. Her understanding of facial anatomy and skin ageing means each treatment is carefully planned for a natural-looking result, with your safety first.

Honest, bespoke planning
Everyone's skin is different. We assess your skin and goals before recommending anything, and if another treatment would suit you better, Dr Cat will say so.

Naturally healthier, still you
Our aim is to restore skin quality, not change your face. You simply look fresher and healthier, rather than treated.
FAQS
Your Polynucleotides Questions Answered
Everything you need to know about Polynucleotides at Teeth & Face. Can't find your answer? Get in touch, and we'll be happy to help.
How much do polynucleotides cost?
What are polynucleotides made from?
Are polynucleotides safe?
Do polynucleotides hurt?
How many polynucleotide treatments will I need?
When will I see polynucleotide results, and how long do they last?
Can polynucleotides help under-eye dark circles and tired eyes?
Can polynucleotides help rosacea?
Can polynucleotides treat the neck and chest?
Who is not suitable for polynucleotides?




